欢迎来到OAJRC平台!

期刊目次

加入编委

期刊订阅

添加您的邮件地址以接收即将发行期刊数据:

Open Access Article

International Journal of Medicine and Data. 2022; 6: (1) ; 64-68 ; DOI: 10.12208/ j.ijmd.20220017.

Clinical study on the benefits of combined application of lumbrokinase and Tongxinluo in elderlypatients with severe cerebral vascular stenosis
重度脑血管狭窄老年脑梗死患者联合应用蚓激酶及通心络的获益临床研究

作者: 贾丽博*, 陈肖东, 张冰, 肖翠君, 梁金排

衡水市人民医院 河北衡水

*通讯作者: 贾丽博,单位:衡水市人民医院 河北衡水;

发布时间: 2022-04-25 总浏览量: 50

摘要

目的 分析重度脑血管狭窄老年脑梗死患者联合应用蚓激酶及通心络的获益临床效果。方法 对照组使用阿司匹林联合瑞舒伐他汀进行治疗,观察组在此基础之上增加蚓激酶联合通心络进行治疗。对比两组患者的血管狭窄程度改善情况、神经系统评分情况以及相关指标变化情况。结果 观察组患者血管狭窄程度改善情况好于对照组,两组之间具有显著差异(P<0.05),观察组患者神经系统评分情况好于对照组,两组之间具有显著差异(P<0.05)。观察组患者血浆D-二聚体,超敏C-反应蛋白相关指标好于对照组,具有显著差异(P<0.05)。观察组治疗有效率高于对照组,不良反应发生率低于对照组,具有显著差异(P<0.05)。结论 蚓激酶联合通心络治疗方法对于重度脑血管狭窄老年脑梗死患者具有良好的治疗效果,经治疗,患者的急性脑血管病变发生概率降低,血管狭窄改善程度良好,且患者的溶栓效果良好,自理能力显著提升,生存质量改善。经治疗,患者的斑块形成以及血管狭窄的炎性介质分泌情况改善,可推广。

关键词: 重度脑血管狭窄;老年脑梗死;蚓激酶;通心络

Abstract

Objective To analyze the clinical effect of combined use of lumbrokinase and Tongxinluo in elderly patients with cerebral infarction with severe cerebral vascular stenosis.
Methods The control group was treated with aspirin combined with rosuvastatin, and the observation group was treated with lumbrokinase combined with Tongxinluo on this basis. The improvement of the degree of vascular stenosis, the score of the nervous system and the changes of related indicators were compared between the two groups.
Results The improvement of the degree of vascular stenosis in the observation group was better than that in the control group, and there was a significant difference between the two groups (P<0.05). 0.05). The plasma D-dimer and high-sensitivity C-reactive protein-related indexes of the observation group were better than those of the control group, with significant difference (P<0.05). The effective rate of treatment in the observation group was higher than that in the control group, and the incidence of adverse reactions was lower than that in the control group, with significant differences (P<0.05).
Conclusion   Lumbrokinase combined with Tongxinluo therapy has a good therapeutic effect on elderly patients with cerebral infarction with severe cerebral vascular stenosis. After treatment, the incidence of acute cerebrovascular disease in patients is reduced, the degree of improvement in vascular stenosis is good, and the thrombolytic effect of patients is improved. Good, the self-care ability has been significantly improved, and the quality of life has improved. After treatment, the patient's plaque formation and the secretion of inflammatory mediators of vascular stenosis improved, which can be promoted.

Key words: Severe cerebral vascular stenosis; Senile cerebral infarction; Lumbrokinase; Tongxinluo

参考文献 References

[1] Zhang L, Wu Y, Jia Z, et al. Protective effects of a compound herbal extract (Tong Xin Luo) on free fatty acid induced endothelial injury: implications of antioxidant system[J]. Bmc Complementary & Alternative Medicine, 2008, 8(1):1-10.

[2] 米国青,薛满忠,傅昱,马洪颖,李莉,王连辉. 通心络治疗对脑梗死患者颈动脉狭窄程度和超敏C反应蛋白及D-二聚体水平的影响[J]. 国际检验医学杂志,2017,38(12):1591-1593. [2017-09-26].

[3] 刘深,王宏涛,魏聪,常成成,吴以岭. 通心络胶囊治疗缺血性脑卒中作用机制研究进展[J]. 中草药,2017,48(11):2321-2326. [2017-09-26].

[4] 陈汉文,何苑英,莫美华,何国锐,吴君杰,吴新宝. 蚓激酶单用与联合小剂量尿激酶治疗急性进展性脑梗死对比观察[J]. 中国医学创新,2017,14(11):17-20. [2017-09-26].

[5] 余能伟, 刘洁, 吴景芬,等. 蚓激酶胶囊改善缺血性脑血管病患者颈动脉粥样硬化斑块的临床研究[J]. 中国医药, 2009, 4(3):169-170.

[6] 李国山. 蚓激酶降纤对缺血性脑卒中患者D-二聚体及CRP水平的影响[J]. 慢性病学杂志, 2016(3):349-350.

引用本文

贾丽博, 陈肖东, 张冰, 肖翠君, 梁金排 重度脑血管狭窄老年脑梗死患者联合应用蚓激酶及通心络的获益临床研究[J]. 国际医学与数据杂志, 2022; 6: (1) : 64-68.