A multicenter retrospective study on calcium gluconate granules in the treatment of calcium deficiency-related diseases
葡萄糖酸钙颗粒治疗钙缺乏相关疾病的多中心回顾性研究

摘要

目的 回顾性分析葡萄糖酸钙颗粒在真实世界临床中治疗钙缺乏相关疾病的疗效和安全性。方法 回顾性分析6家医院及社区卫生服务中心收集的1000例骨质疏松和低钙血症患者的临床资料，统计服用葡萄糖酸钙颗粒联合西医基础治疗后的临床症状评分（腰背疼痛、乏力、四肢活动受限）、血清总钙和骨密度的变化，以及其他安全性指标，并记录不良事件。结果 治疗后骨质疏松和低钙血症患者临床症状评分显著降低（P<0.01），血清总钙显著升高（P<0.05），骨质疏松患者骨密度改善但无统计学意义（P>0.05）。治疗期间共出现8例不良事件，经判断与葡萄糖酸钙颗粒可能相关不良反应5例次。结论 葡萄糖酸钙颗粒用于钙缺乏疾病如骨质疏松和低钙血症疗效显著且安全性良好，能有效改善临床症状和钙水平，对骨密度短期影响不明显。

Abstract

Objective To retrospectively analyze the efficacy and safety of calcium gluconate granules in the treatment of calcium deficiency-related diseases in real-world clinical practice.
Methods Clinical data from 1000 patients with osteoporosis and hypocalcemia were retrospectively analyzed, collected from six hospitals and community health service centers. Statistics were compiled on clinical symptom scores (including low back pain, fatigue, and limited limb mobility), changes in serum total calcium and bone mineral density, as well as other safety indicators following treatment with calcium gluconate granules combined with conventional Western medical therapy. Adverse events were also recorded.
Results After treatment, clinical symptom scores in patients with osteoporosis and hypocalcemia were significantly reduced (P<0.01). Serum total calcium increased significantly (P<0.05). Bone mineral density improved in osteoporosis patients, but the change was not statistically significant (P>0.05). During the treatment period, a total of 8 adverse events were reported, of which 5 were considered potentially related to calcium gluconate granules.
Conclusion   Calcium gluconate granules demonstrate significant efficacy and favorable safety in the treatment of calcium deficiency-related diseases such as osteoporosis and hypocalcemia. They effectively improve clinical symptoms and calcium levels, although their short-term impact on bone mineral density is not pronounced.