Evaluation of the efficacy of prophylactic antibiotic use strategies in reducing the risk of infection and bleeding after abdominal surgery
预防性抗生素使用策略在减少腹部手术后感染与出血风险中的效果评价

摘要

目的 探究预防性抗生素使用策略在减少腹部手术后感染与出血风险的效果。方法 我们选择了对照组及研究组各38例进行抗生素使用策略的比较分析，对照组采用常规抗生素使用策略，而研究组则采用预防性抗生素使用策略。结果 结果显示，研究组患者的C反应蛋白水平以及白细胞下降情况较对照组更优越（P<0.05）；研究组的抗生素剂量较小，种类更多，使用时机及ICU停留时间短于对照组（P<0.05）；在不良事件方面，研究组的感染、过敏、呼吸困难及咳痰率显著低于对照组（P<0.05）。结论 预防性抗生素使用策略在减少腹部手术后的感染与出血风险方面有显著效果，尤其在降低感染率、缩短ICU停留时间、减少不良反应发生等方面优于常规抗生素使用策略。

Abstract

Objective To explore the effect of prophylactic antibiotic use strategies in reducing the risk of infection and bleeding after abdominal surgery.
Methods We selected 38 cases from each of the control group and the study group for a comparative analysis of antibiotic use strategies. The control group adopted a conventional antibiotic use strategy, while the study group adopted a prophylactic antibiotic use strategy.
Results The results showed that the C-reactive protein level and the decrease of white blood cells in the study group were superior to those in the control group (P<0.05). The study group had a smaller antibiotic dosage, a greater variety of antibiotics, and a shorter usage time and ICU stay time than the control group (P<0.05). In terms of adverse events, the infection, allergy, dyspnea and expectoration rates in the study group were significantly lower than those in the control group (P<0.05).
Conclusion   The prophylactic antibiotic use strategy has a significant effect in reducing the risk of infection and bleeding after abdominal surgery, and is superior to the conventional antibiotic use strategy, especially in reducing the infection rate, shortening the ICU stay time, and reducing the occurrence of adverse reactions.