Research on individualized antihypertensive drug therapy strategies based on pharmacogenomics
基于药物基因组学的个体化抗高血压药物治疗策略研究

摘要

个体化抗高血压药物治疗策略是基于药物基因组学的一个重要研究方向。药物基因组学通过分析患者的基因变异，能够为高血压患者提供更加精准的药物选择，避免药物的副作用，提高治疗效果。随着高血压患病率的上升，传统的“一刀切”治疗方式已难以满足患者个性化需求。结合基因组数据来制定治疗方案，已成为提高治疗效率和患者依从性的重要途径。本研究旨在探讨如何运用药物基因组学原理优化个体化抗高血压治疗方案，分析基因与药物反应的关系，提出个性化治疗方案的设计思路和实施策略。基因组学的应用能够有效指导药物选择，降低副作用，提升疗效，为高血压治疗提供新的方向。

Abstract

The strategy of individualized antihypertensive drug therapy is an important research direction based on pharmacogenomics. By analyzing patients' genetic variations, pharmacogenomics can provide more precise drug choices for hypertensive patients, avoid drug side effects, and improve treatment efficacy. With the rising prevalence of hypertension, the traditional "one-size-fits-all" treatment approach can no longer meet patients' personalized needs. Developing treatment plans based on genomic data has become a crucial way to enhance treatment efficiency and patient compliance. This study aims to explore how to apply pharmacogenomic principles to optimize individualized antihypertensive treatment regimens, analyze the relationship between genes and drug responses, and propose design ideas and implementation strategies for personalized treatment plans. The application of genomics can effectively guide drug selection, reduce side effects, enhance therapeutic effects, and provide a new direction for hypertension treatment.