欢迎来到OAJRC平台！

期刊栏目

投稿

审稿

期刊目次

加入编委

期刊订阅

添加您的邮件地址以接收即将发行期刊数据：

当前位置：国际医学与数据杂志 > 2025年 9卷 (1)期

Open Access Article

International Journal of Medicine and Data. 2025; 9: (1) ; 1-4 ; DOI: 10.12208/j.ijmd.20250001.

Advances in pharmacological action and molecular mechanism of Isobavachalcone ethyl
补骨脂乙素药理作用及分子机制的研究进展

作者： 梁宏雪¹, 侯文爽², 黄曦醇², 宁钊², 蒋蕾¹ *, 金成浩² *

¹哈尔滨医科大学大庆校区药学院黑龙江大庆

²黑龙江八一农垦大学生命科学技术学院黑龙江大庆

*通讯作者：蒋蕾,单位：哈尔滨医科大学大庆校区药学院黑龙江大庆；金成浩,单位：黑龙江八一农垦大学生命科学技术学院黑龙江大庆；

发布时间: 2025-01-26 总浏览量: 532

PDF 全文下载引用本文

摘要

补骨脂是豆科补骨脂属，一年生草本植物，常用于治疗肾阳不足、肾虚作喘及腰膝冷痛等病症。补骨脂乙素是一种从中药补骨脂果实中分离出的查尔酮类化合物。研究报道，补骨脂乙素具有良好的抗肿瘤、抗炎、抑菌及抗哮喘等多种药理作用。本文对补骨脂乙素的药理作用及分子机制进行综述，旨在为补骨脂乙素的深入研究与新药开发提供理论支持。

关键词： 补骨脂乙素；抗肿瘤；抗炎；抑菌；抗哮喘

Abstract

Psoralen is an annual herb of the leguminous genus Psoralen. It is often used to treat diseases such as deficiency of kidney Yang, asthenia of kidney and cold pain of waist and knee. Isobavachalcone is a chalcone compound isolated from the fruit of the traditional Chinese medicine psoralen. Studies have reported that isobavachalcone has good pharmacological effects such as anti-tumor, anti-inflammatory, anti-bacteria and anti-asthma. This article reviews the pharmacological action and molecular mechanism of isobavachalcone, aiming to provide theoretical support for the in-depth research and new drug development of isobavachalcone.

Key words： Isobavachalcone; Anti-tumor; Anti-inflammatory; Anti-bacteria; Anti-asthma

参考文献 References

[1] 鄢羽欣, 王红丽, 黄锦贤, 等. 补骨脂性味功效及用药禁忌考证[J/OL]. 辽宁中医药大学学报, 2024, 1-18.

[2] 宋利利, 王伟卫, 孙云, 等. 补骨脂乙素诱导伊马替尼敏感和耐药的慢性粒细胞白血病细胞凋亡[J]. 上海交通大学学报(医学版), 2014, 34(09): 1309-1314.

[3] Luan L, Shen X, Liu X, et al. Qualitative analysis of Psoraleae Fructus by HPLC-DAD/TOF-MSfingerprint and quantitative analysis of multiple components by single marker. Biomed Chromatogr. 2018, 32(2).

[4] 任亚利, 赵桂英, 饶华楠, 等. 补骨脂乙素通过调控Sirtuins相关信号通路抑制非小细胞肺癌进程[J]. 中药与临床, 2022, 13(04): 33-37+53.

[5] Li Y, Qin X, Li P, et al. Isobavachalcone isolated from Psoralea corylifolia inhibits cell proliferation and induces apoptosis via inhibiting the AKT/GSK-3β/β-catenin pathway in colorectal cancer cells. Drug Des Devel Ther. 2019, 13: 1449-1460.

[6] 任亚利. 补骨脂乙素通过靶向SIRT2和诱导ROS相关通路抗三阴性乳腺癌增殖[D]. 成都中医药大学, 2022.

[7] 史毅, 金晓红, 吴伟忠, 等. 补骨脂乙素对舌鳞状细胞癌Tca8113细胞增殖的抑制作用和凋亡诱导作用及其机制[J]. 吉林大学学报(医学版), 2016, 42(04): 725-730.

[8] 王安红, 卢国彦, 周昆, 等. 补骨脂乙素诱导HepG2细胞凋亡及对Bcl-2家族表达的影响[J]. 中药药理与临床, 2012, 28(05): 23-25.

[9] 史毅, 吴伟忠, 霍安, 等. 补骨脂乙素对Tca8113细胞迁移及侵袭的抑制作用及其机制[J]. 中国药理学通报, 2015, 31(12): 1741-1745.

[10] 陈胜, 刘云, 王天宝, 等. 异补骨脂查耳酮对前列腺癌细胞PC3增殖、迁移、凋亡、侵袭的影响[J]. 中国药业, 2023, 32(08): 39-43.

[11] 肖毅, 李佩佩, 周劲, 等. 异补骨脂查耳酮对鼻咽癌CNE1细胞增殖和转移的影响及作用机制的研究[J]. 中国药师, 2021, 24(09): 1623-1629.

[12] Gao D, Liu F, Li Z, et al. Isobavachalcone attenuates Sephadex-induced lung injury via activation of A20 and NRF2/HO-1 in rats. Eur J Pharmacol. 2019, 848: 49-54.

[13] Dong WH, Chu QQ, Liu SQ, et al. Isobavachalcone ameliorates diabetic nephropathy in rats by inhibiting the NF-κB pathway. Food Biochem. 2020, 44(9): e13405.

[14] 关丽杰, 赵礼慧, 董瑞芳. 异补骨脂查尔酮对苹果腐烂病菌菌丝形态及细胞结构的影响[J]. 农药, 2014, 53(04): 290-292.

[15] Liu XW, Yang YJ, Qin Z, et al. Isobavachalcone From Cullen corylifolium Presents Significant Antibacterial Activity Against Clostridium difficile Through Disruption of the Cell Membrane. Front Pharmacol. 2022, 13: 914188.

[16] Mahajan SG, Mehta AA. Suppression of ovalbumin-induced Th2-driven airway inflammation by β-sitosterol in a guinea pig model of asthma. Eur J Pharmacol. 2011, 650(1): 458-464.

[17] Bousquet J, Jeffery PK, Busse WW, et al. Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med. 2000, 161(5): 1720-1745.

[18] 梁正, 郝文龙, 孙雪英, 等. 异补骨脂查尔酮抗哮喘作用的实验研究[J]. 湖南中医杂志, 2016, 32(05): 177-179.

引用本文

梁宏雪, 侯文爽, 黄曦醇, 宁钊, 蒋蕾, 金成浩, 补骨脂乙素药理作用及分子机制的研究进展[J]. 国际医学与数据杂志, 2025; 9: (1) : 1-4.

入驻平台

回到首页

搜索文章: