Evaluation of levofloxacin combined with metronidazole in the treatment of postoperative infection in patients with acute appendicitis
左氧氟沙星联合甲硝唑治疗急性阑尾炎患者术后感染的评价

摘要

目的 探究在急性阑尾炎患者中采用联合药物疗法（左氧氟沙星+甲硝唑）对患者术后感染的治疗效果。方法 选取2023年4月-2024年4月期间本院收治的60例急性阑尾炎患者（均发生术后感染并发症），根据随机抽样法将其分为实验组（30例，采用左氧氟沙星+甲硝唑联合疗法）和对照组（30例，采用单用甲硝唑疗法）。对比两组治疗前、治疗3d后的炎症指标（CRP/C反应蛋白、WBC/白细胞计数）和治疗后患者退热时间、伤口愈合时间、术后住院时间，以及治疗期间患者的不良反应（恶心、呕吐、眩晕）发生情况。结果 治疗前两组的炎症指标和治疗期间两组的不良反应发生率对比，均无显著性差异 （P＞0.05）；治疗3d后，实验组的CRP与WBC指标均低于对照组，且实验组的退热、伤口愈合和术后住院时间都比对照组短 （P＜0.05）。结论 左氧氟沙星+甲硝唑联合疗法治疗急性阑尾炎患者术后感染的临床效果显著，优于单用甲硝唑疗法，且安全性有保障。

Abstract

Objective To explore the effect of combined drug therapy (levofloxacin + metronidazole) on postoperative infection in patients with acute appendicitis.
Methods Sixty patients with acute appendicitis admitted to our hospital from April 2023 to April 2024 (all with postoperative infection complications) were selected and divided into experimental group (30 cases with levofloxacin plus metronidazole) and control group (30 cases with metronidazole alone) according to random sampling method. The inflammatory indicators (CRP/ C-reactive protein, WBC/ white blood cell count), the time of fever reduction, wound healing, postoperative hospitalization, and the occurrence of adverse reactions (nausea, vomiting, vertigo) during treatment were compared between the two groups before and after treatment for 3 days.
Results There was no significant difference between the two groups before treatment and the incidence of adverse reactions during treatment (P > 0.05). After 3 days of treatment, CRP and WBC indexes in the experimental group were lower than those in the control group, and fever reduction, wound healing and postoperative hospital stay in the experimental group were shorter than those in the control group (P < 0.05).
Conclusion   The combined therapy of levofloxacin and metronidazole in the treatment of postoperative infection in patients with acute appendicitis has a significant clinical effect, which is better than metronidazole alone, and the safety is guaranteed.