Research on the application of ECMO in severe pneumonia
ECMO在重症肺炎中的应用研究

摘要

目的 研究重症肺炎治疗中应用ECMO（体外膜肺氧合）的有效价值。方法 将2022年10月-2023年12月时间内受诊的重症肺炎患者88例列入观察范围，以数字表法的形式进行两组划分，即基础机械通气干预的基础干预组、体外膜肺氧合干预的氧合干预组，对比两组身体指标变化情况、治疗效果。结果 氧合干预组16例患者属于病情明显好转结果、25例患者属于病情一般好转结果、3例患者属于病情无好转结果，病情好转率是93.2%，较基础干预组86.4%高，p<0.05；治疗后，氧合干预组氧合指数项目均值（11.25±3.40）%、血氧分压项目均值（54.78±5.18）mmHg、二氧化碳分压项目均值（51.45±3.55）mmHg、气道阻力项目均值（40.55±4.67）cmH2O/（L·s），均较基础干预组优，p<0.05；氧合干预组不良反应出现率是4.6%，较基础干预组11.4%低（2例感染现象、2例胃肠道不舒适现象、1例异常疼痛现象），p<0.05。结论 重症肺炎的治疗中，应及时引进ECMO技术，提高病情好转率，促进呼吸指标改善，保障治疗安全性。

Abstract

Objective To study the effective value of ECMO (extracorporeal membrane oxygenation) in the treatment of severe pneumonia.
Methods 88 severe pneumonia patients diagnosed between October 2022 and December 2023 were included in the observation range. Two groups were divided using a digital table method, namely the basic intervention group of basic mechanical ventilation intervention and the oxygenation intervention group of extracorporeal membrane oxygenation intervention. The changes in physical indicators and treatment effects of the two groups were compared.
Results In the oxygenation intervention group, 16 patients had a significant improvement in their condition, 25 patients had a general improvement in their condition, and 3 patients had no improvement in their condition. The improvement rate was 93.2%, which was higher than 86.4% in the basic intervention group (p<0.05); After treatment, the mean oxygenation index (11.25 ± 3.40)%, mean blood oxygen partial pressure (54.78 ± 5.18) mmHg, mean carbon dioxide partial pressure (51.45 ± 3.55) mmHg, and mean airway resistance (40.55 ± 4.67) cmH2O/(L · s) in the oxygenation intervention group were all better than those in the basic intervention group, p<0.05; The incidence of adverse reactions in the oxygenation intervention group was 4.6%, which was lower than 11.4% in the basic intervention group (2 cases of infection, 2 cases of gastrointestinal discomfort, and 1 case of abnormal pain), p<0.05.
Conclusion   In the treatment of severe pneumonia, ECMO technology should be introduced in a timely manner to increase the improvement rate of the condition, promote the improvement of respiratory indicators, and ensure the safety of treatment.