摘要
金钗石斛是一种属于兰科石斛属的附生型多年生草本植物，作为我国传统中药已被广泛应用多年，具有抗炎镇痛、滋阴清热、益胃生津的功效，常用于治疗肿瘤、神经受损等病症，近年来备受关注。石斛碱是从金钗石斛茎中提取分离的一种天然生物碱类物质，是一种含有15个碳的Picrotoxane型 倍半萜类生物碱，具有抗癌、抗炎、抗甲型流感病毒、治疗白血病、治疗帕金森病、保护内脏器官及促进细胞成熟等多种生物学活性。因目前对石斛碱的药理作用及其机制研究正处起步阶段，本文将 围绕石斛碱的药理作用及其分子机制的相关研究进展进行综述，以期为石斛碱的应用研究与药物开发提供一定的理论基础。
关键词： 石斛碱；抗癌；抗炎；抗甲型流感病毒；治疗白血病
Abstract
Dendrobium nobilis is an epiphytic perennial herb belonging to Dendrobium genus in the orchid family. As a traditional Chinese medicine, it has been widely used for many years, which has the effects of anti-inflammatory and analgesic, nourishing Yin and clearing heat, benefiting stomach and promoting fluid. It is often used in the treatment of tumors, nerve damage and other diseases, and has attracted much attention in recent years. Dendrobine is a kind of natural alkaloid substance extracted and separated from the stem of Dendrobium nobile. It is a Picrotoxane sesquiterpenoid alkaloid containing 15 carbon. It has various biological activities such as anti-cancer, anti-inflammation, anti-influenza A virus, treatment of leukemia, treatment of Parkinson's disease, protection of internal organs and promotion of cell maturation. Because the study on the pharmacological action and mechanism of dendrobine is in the initial stage, this article will review the progress of the pharmacological action and molecular mechanism of dendrobine, in order to provide a certain theoretical basis for the application research and drug development of dendrobine.
Key words： Dendrobine; Anti-cancer; Anti-inflammation; Anti-influenza a virus; Treatment of leukemia
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