Advances in pharmacological action and molecular mechanism of Osthole
蛇床子素的药理作用及其分子机制研究进展

摘要

蛇床子是一种伞形科一年生草本植物，是一种传统的中药材，又名为野茴香，具有良好的燥湿祛风、温肾壮阳及解毒止痛等功效，常用于治疗肿瘤、癣疮及类风湿等病症，近年来逐渐被世界认识并接受。蛇床子素是从蛇床子中提取分离的一种香豆素类化合物，是一种天然植物源农药的活性物质。研究发现，蛇床子素具有抗癌、抗炎、防治心血管疾病、神经保护、抗氧化以及降血糖等多种药理作用。因目前对蛇床子素的药理活性及其作用机制研究正处研究初期，本文将 围绕蛇床子素的药理作用及其分子机制的相关研究进展进行综述，旨在为蛇床子素的进一步基础研究和临床应用提供新思路。

Abstract

Cnidium monnieri is a kind of annual herb in the umbraceae family, is a traditional Chinese medicine, also known as wild fennel, with good effects of drying dampness and wind, warming kidney and aphrodisiac, detoxification and pain relief, and is often used in the treatment of tumors, tinea sores and rheumatoid diseases, and has gradually been recognized and accepted by the world in recent years. Osthole is a coumarin compound extracted from cnidium monnieri. It is an active substance of natural plant pesticide. Studies have found that osthole has anticancer, anti-inflammation, prevention and treatment of cardiovascular diseases, neuroprotection, antioxidant and hypoglycemic effects. Because the current research on the pharmacological activity and mechanism of osthole is in the early stage, this paper will review the relevant research progress on the pharmacological action and molecular mechanism of osthole, aiming to provide new ideas for further basic research and clinical application of osthole.