Curative effect of papaverine on coronary spasm angina pectoris
罂粟碱用于冠脉痉挛性心绞痛的疗效观察

摘要

目的 讨论罂粟碱用于冠脉痉挛性心绞痛的疗效。方法 纳入76例冠脉痉挛性心绞痛的患者，随机分2组，每组38例。对照组开展常规对症治疗，治疗组对照组基础上加用罂粟碱。比较两组的总有效率、心绞痛发病情况、心绞痛疼痛程度及心肌损伤程度。结果 总有效率比较，治疗组（94.74%）与对照组（78.95%）相比显著更高（P＜0.05）；与对照组比较，治疗组心绞痛发作频率明显更少，平均发作时间明显更短（P＜0.05）；治疗组与对照组比较，治疗组心绞痛发作程度更轻（P＜0.05）；治疗组与对照组比较，肌钙蛋白I（Cardiac troponin I，cTnI）、肌酸激酶同工酶（CK-MB）显著更低（P＜0.05）。结论 常规治疗后加用罂粟碱对冠脉痉挛性心绞痛患者进行治疗，可减轻患者心绞痛发作次数和疼痛程度，改善心绞痛症状，缩短其发病时间，有助于促使患者恢复，治疗效果较为显著。

Abstract

Objective To discuss the effect of papaverine on coronary spasm angina pectoris.
Methods 76 patients with coronary spasm angina pectoris were randomly divided into two groups, 38 patients in each group. The control group was treated with conventional symptomatic treatment, and the treatment group was treated with papaverine on the basis of the control group. The total effective rate, incidence of angina pectoris, degree of angina pectoris pain and degree of myocardial injury were compared between the two groups.
Results The total effective rate of the treatment group(94.74%)was significantly higher than that of the control group(78.95%), (P<0.05); Compared with the control group, the frequency of angina pectoris attack in the treatment group was significantly less, and the average attack time was significantly shorter(P<0.05);Compared with the control group, the attack of angina pectoris in the treatment group was milder(P<0.05);Compared with the control group, cardiac troponin I(cTnI)and creatine kinase isoenzyme(CK-MB)in the treatment group were significantly lower(P<0.05).
Conclusion   The addition of papaverine to the treatment of patients with coronary spasm angina pectoris after routine treatment can reduce the number and degree of angina pectoris, improve the symptoms of angina pectoris, shorten the onset time, help to promote recovery of patients, and the treatment effect is relatively significant.