Protective effect and improvement of dexmedetomidine in patients with craniocerebral injury
右美托咪定对颅脑损伤患者的脑保护作用及改善效果探究

摘要

目的 对于临床毒脑外伤患者为手术期右美托咪定的保护作用进行探讨。方法 选择河南省南阳南石医院2021年1月至2023年3月间所谓收治的100例颅脑损伤患者作为研究对象，以入院先后顺序将两组患者均分为对照组（n=50）及实验组（n=50）。针对上述两组患者在进行麻醉诱导前分别使用生理盐水和右美托米定。在此基础上对两组患者麻醉状况、手术时间等进行对比。结果 两种患者在麻醉时间和手术时间方面相比较无明显差异，P>0.05；与对照组相比较，试验组患者在手术过程中瑞芬太尼用量明显跟上，差异显著，P<0.05。两组患者在不同时间节点的各项恢复指标上面相比较，手术结束时两组患者的各项评分无明显差异，P>0.05；其他各时间节点两组患者各项恢复指标对比存在明显差异，差异显著，P<0.05。结论 在麻醉诱导前通过使用右美脱敏定可有效减少颅脑损伤患者手术过程中瑞芬太尼的整体用量，可对患者脑部形成良好保护，同时对于患者预后免疫功能也有积极改善效果，可实现患者炎症反应有效控制，对患者术后恢复有积极作用。

Abstract

Objective To investigate the protective effect of dexmedetomidine in patients with toxic brain injury during operation.
Methods The so-called 100 cases of craniocerebral injury patients admitted to Nanyang Hospital in Henan Province from January 2021 to March 2023 were selected as the study object. The two groups of patients were divided into control group (n=50) and experimental group (n=50) in order of admission. Normal saline and dexmetomidine were respectively used in the two groups before anesthesia induction. On this basis, the anesthesia status and operation time of the two groups were compared.
Results There was no significant difference in anesthesia time and operation time between the two patients, P>0.05. Compared with the control group, the dosage of remifentanil in experimental group kept up significantly during the operation, and the difference was significant (P<0.05). The two groups were compared in various recovery indexes at different time nodes, and there was no significant difference in the scores of the two groups at the end of the operation, P>0.05. At other time nodes, there were significant differences in various recovery indicators between the two groups (P<0.05).
Conclusion   The use of dextromedesensitization before anesthesia induction can effectively reduce the overall dosage of remifentanil in patients with cranial brain injury during surgery, which can form a good protection for the brain of patients, and also has a positive effect on the prognosis of patients with immune function, can achieve effective control of patients' inflammatory response, and has a positive effect on the postoperative recovery of patients.