Effect of intrathecal amphotericin B+5-fluorocytosine injection on bacterial meningitis in children
鞘内注射两性霉素B+5-氟胞嘧啶治疗小儿细菌性脑膜炎的效果分析

摘要

目的 探究为治疗小儿细菌性脑膜炎，选择应用鞘内注射两性霉素B+5-氟胞嘧啶治疗的效果。方法 本医院所有患儿均采用计算机随机分组，60例小儿细菌性脑膜炎患者被平均分为观察组（n=30）和对照组（n=30），前者应用鞘内注射两性霉素B+5-氟胞嘧啶，后者用静脉滴注两性霉素B和5-氟胞嘧啶，实施时间为2021年1月至2022年1月。将两组患儿的临床疗效、相关恢复时间指标进行比较。结果 在总有效率控制方面，两组数据差异很大，观察组、对照组分别为96.67%、86.67%（P＜0.05）；在白细胞恢复正常、体温恢复正常以及住院时间对照上，观察组分别为（6.35±1.25）d、（10.65±2.18）d、（15.35±5.24）d，与对照组（8.63±2.10）d、（12.25±2.45）d、（21.03±5.52）d相比，前者明显较短（P＜0.05）。结论 为治疗小儿细菌性脑膜炎，选择应用鞘内注射两性霉素B+5-氟胞嘧啶治疗疗效明显，可缩短患儿的恢复时间。

Abstract

Objective To investigate the effect of intrathecal amphotericin B+5-fluorocytosine injection on bacterial meningitis in children.
Methods All children in our hospital were randomly divided into two groups by computer. Sixty children with bacterial meningitis were equally divided into the observation group (n=30) and the control group (n=30). The former received intrathecal amphotericin B+5-fluorocytosine, and the latter received intravenous amphotericin B and 5-fluorocytosine. The implementation time was from January 2021 to January 2022. The clinical efficacy and relevant recovery time indexes of the two groups were compared.
Results In terms of total effective rate control, there was a great difference between the two groups, 96.67% in the observation group and 86.67% in the control group (P<0.05); On the control of white blood cells returning to normal, body temperature returning to normal and hospital stay, the observation group was (6.35±1.25) d, (10.65±2.18) d, (15.35±5.24) d respectively, which was significantly shorter than the control group (8.63±2.10) d, (12.25±2.45) d, and (21.03±5.52) d (P<0.05).
Conclusion   In order to treat bacterial meningitis in children, intrathecal amphotericin B+5-fluorocytosine injection is effective and can shorten the recovery time of children.