摘要
目的 探究LRG1在乳腺癌组织中的表达及对MCF-7细胞侵袭和迁移的影响。方法 选择医院2022年1月至2022年12月50例乳腺癌患者为研究对象，利用免疫组化以及免疫荧光染色对乳腺组织LRG1表达情况进行观察，并且针对LRG1抑制MCF-7细胞侵袭和迁移的影响进行研究。结果 50例乳腺癌组织中均存在LRG1表达，癌旁组织中仅存在1例低表达，数据差异显著（P＜0.05）；LRG1表达MCF-7细胞侵袭和迁移能力降低。结论 乳腺癌LRG1组织的高表达与患者病症严重程度以及转移情况有密切关联，降低LRG1能够减少MCF-7细胞侵袭和迁移能力，可以为临床疾病治疗提供科学辅助指导。
关键词： LRG1表达；乳腺癌组织；MCF-7；细胞侵袭；迁移
Abstract
Objective To investigate the expression of LRG1 in breast cancer tissues and its effect on invasion and migration of MCF-7 cells. Methods 50 patients with breast cancer from January 2022 to December 2022 were selected as the research objects. Immunohistochemistry and immunofluorescence staining were used to observe the expression of LRG1 in breast tissue, and the effect of LRG1 on inhibiting the invasion and migration of MCF-7 cells was studied. Results LRG1 expression was found in all 50 breast cancer tissues, and low expression was found in only 1 paracancer tissue, the data difference was significant (P < 0.05). The invasion and migration ability of MCF-7 cells expressed by LRG1 were decreased. Conclusion The high expression of LRG1 tissue in breast cancer is closely related to the severity of disease and metastasis of patients. Reducing LRG1 can reduce the invasion and migration ability of MCF-7 cells, which can provide scientific guidance for clinical disease treatment.
Key words： LRG1 expression; Breast cancer tissue; MCF-7; Cell invasion; migration
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