The relationship between CDX2, RKIP, lncRNA BC200 and chronic atrophic gastritis and its predictive value for secondary gastric cancer
CDX2、RKIP、lncRNA BC200与慢性萎缩性胃炎的关系及对继发胃癌的预测价值

摘要

目的 分析尾侧型同源转录因子-2（CDX2）、Raf激酶抑制蛋白（RKIP）、lncRNA BC200与慢性萎缩性胃炎的关系及对继发胃癌的预测价值。方法 选取2020年11月-2021年11月期间在我院进行治疗的慢性萎缩性胃炎142例进行前瞻性预测价值研究，同时选取在我院进行治疗的胃癌患者88例，进行Westernbiot法对检测lncRNA BC200的表达。结果 胃癌组患者CDX2、lncRNA BC200表达高于萎缩组、非萎缩组，RKIP表达低于萎缩组、非萎缩组；萎缩组患者CDX2、lncRNA BC200表达高于非萎缩组，RKIP表达低于非萎缩组；具有统计学差异（P＜0.05）。ROC曲线显示，与CDX2、RKIP、lncRNA BC200单项预测相比，三项联合对慢性萎缩性胃炎的关系及对继发胃癌的预测价值较高（P＜0.05）。结论 检测CDX2、RKIP、lncRNA BC200与慢性萎缩性胃炎的关系及对继发胃癌的风险具有一定预测价值，以早期制定相关措施干预，提高治疗效率。

Abstract

Objective: To analyze the relationship between caudal homologous transcription factor-2 (CDX2), Raf kinase inhibitor protein (RKIP), lncRNA BC200 and chronic atrophic gastritis (CAG) and their predictive value for secondary gastric cancer.
Methods: 142 patients with chronic atrophic gastritis who were treated in our hospital from November 2020 to November 2021 were selected for a prospective predictive value study. At the same time, 88 patients with gastric cancer who were treated in our hospital were selected for Western biot method to detect the expression of lncRNA BC200.
Results: The expression of CDX2 and lncRNA BC200 in gastric cancer group was higher than that in atrophic group and non atrophic group, while the expression of RKIP was lower than that in atrophic group and non atrophic group; The expression of CDX2 and lncRNA BC200 in atrophic group was higher than that in non atrophic group, and the expression of RKIP was lower than that in non atrophic group; There was statistical difference (P<0.05). ROC curve showed that compared with single prediction of CDX2, RKIP and lncRNA BC200, the three combinations had higher predictive value for chronic atrophic gastritis and secondary gastric cancer (P<0.05).
Conclusion  : The detection of the relationship between CDX2, RKIP, lncRNA BC200 and chronic atrophic gastritis and the risk of secondary gastric cancer has a certain predictive value, in order to develop early intervention measures to improve the treatment efficiency.