Efficacy and safety of aripiprazole combined with olanzapine in the treatment of female schizophrenia
阿立哌唑联合奥氮平治疗女性精神分裂症患者的疗效及安全性分析

摘要

目的 探究阿立哌唑联合奥氮平治疗女性精神分裂症患者的临床效果。方法 选取我院2018年1月到2020年12月128例女性精神分裂症患者，按照治疗方案不同分为联合组、对照组，每组64例。联合组采用奥氮平+阿立哌唑治疗，对照组仅给予奥氮平治疗，比较两组治疗效果、不良反应发生情况。结果 治疗后，联合组总有效率92.19%明显高于对照组71.88%（P＜0.05）；治疗后，联合组嗜睡、体重增加、月经紊乱情况均少于对照组（P＜0.05）。结论 奥氮平治疗女性精神分裂症患者基础上加用阿立哌唑治疗能进一步改善其血糖血脂水平，提高临床疗效，减少不良反应发生情况。

Abstract

Objective: To To explore the clinical effect of aripiprazole combined with olanzapine in the treatment of female schizophrenia.
Methods: 128 female schizophrenics in our hospital from January 2018 to December 2020 were selected and divided into a combined group and a control group according to different treatment schemes, with 64 patients in each group. The combined group was treated with olanzapine+aripiprazole, while the control group was only treated with olanzapine. The therapeutic effects and adverse reactions of the two groups were compared.
Results: After treatment, the total effective rate of the combined group was 92.19% higher than that of the control group (71.88%, P<0.05); After treatment, sleepiness, weight gain and menstrual disorder in the combined group were less than those in the control group (P<0.05).
Conclusion  : Olanzapine plus aripiprazole can further improve the blood glucose and lipid levels, improve clinical efficacy and reduce adverse reactions in female schizophrenia patients.