Clinical analysis of 32 cases of chronic obstructive pulmonary disease
慢性阻塞性肺疾病32例大内科临床治疗分析

摘要

目的 分析慢性阻塞性肺疾病32例大内科临床治疗方法和效果。方法 选择我院2021年1月-2022年1月慢性阻塞性肺疾病患者共32例，数字表随机分2组每组16例，对照组的患者给予特布他林治疗，观察组在该基础上增加丙酸氟替卡松与谷胱甘肽。比较治疗前后患者第一秒用力呼气容积、肺活量、呼气峰流速、外周细胞免疫功能、炎症指标肿瘤坏死因子-α、白细胞介素-6和超敏C反应蛋白、总有效率、不良反应。结果 观察组治疗后患者第一秒用力呼气容积、肺活量、呼气峰流速、外周细胞免疫功能高于对照组，炎症指标肿瘤坏死因子-α、白细胞介素-6和超敏C反应蛋白低于对照组，总有效率高于对照组，P＜0.05。两组治疗过程不良反应没有明显差异，P＞0.05。结论 特布他林联合糖皮质激素与谷胱甘肽对于慢性阻塞性肺疾病的治疗效果确切。

Abstract

Objective: To analyze the clinical treatment methods and effects of 32 cases of chronic obstructive pulmonary disease (COPD).
Methods: A total of 32 patients with chronic obstructive pulmonary disease in our hospital from January 2021 to January 2022 were selected. The number table was randomly divided into two groups: 16 patients in each group. The patients in the control group were treated with terbutaline, and the patients in the observation group were added with fluticasone propionate and glutathione on this basis. Compare the forced expiratory volume, vital capacity, peak expiratory flow rate, peripheral cellular immune function and inflammatory index tumor necrosis factor before and after treatment- α, Interleukin-6 and high-sensitivity C-reactive protein, total effective rate and adverse reaction.
Results: The forced expiratory volume, vital capacity, peak expiratory flow rate and peripheral cellular immune function of patients in the observation group were higher than those in the control group after treatment, and the inflammatory index, tumor necrosis factor-α, Interleukin-6 and high-sensitivity C-reactive protein were lower than those in the control group, and the total effective rate was higher than that in the control group (P<0.05). There was no significant difference in adverse reactions between the two groups (P>0.05).
Conclusion  : Terbutaline combined with glucocorticoid and glutathione is effective in the treatment of chronic obstructive pulmonary disease.