Clinical effect of aspirin enteric coated tablets in the treatment of transient ischemic attack
短暂性脑缺血发作治疗中阿司匹林肠溶片临床效果观察

摘要

目的 对临床短暂性脑缺血发作治疗中阿司匹林肠溶片的应用效果进行探讨。方法 以我院2020年3月至2022年3月间收治的90例短暂性脑缺血发作患者为研究对象，根据治疗方案将两组均分为对照组（n=45）及观察组（n=45），对照组患者在治疗中使用的是氯吡格雷进行干预，而观察组治疗中使用的是阿司匹林肠溶片。对两组患者治疗前后凝血酶活化时间（APTT）、血浆纤维蛋白原（FIB）、凝血酶原时间（PT）、血小板计数（PLT）以及整体治疗有效率进行对比。结果 两组患者在治疗前各项指标无明显差异，P>0.05。经药物治疗干预后，两种患者血小板计数无明显差异，P>0.05。观察组患者血浆纤维蛋白原明显低于对照组，凝血酶活化时间、凝血酶原时间方面，观察组患者明显长于对照组，差异显著，P<0.05。两组患者在整体治疗有效率方面相比较。观察组患者明显更优。差异显著，P<0.05。结论 在临床治疗短暂性脑缺血发作的过程中阿司匹林肠溶片具有更加明显的治疗效果，经营药物干预后患者凝血功能指标可以得到积极改善，具有极大临床推广价值。

Abstract

Objective To investigate the effect of aspirin enteric coated tablets in the treatment of transient ischemic attack (TIA).
Methods 90 patients with transient ischemic attack admitted in our hospital from March 2020 to March 2022 were taken as the research object. According to the treatment plan, the two groups were divided into the control group (n=45) and the observation group (n=45). The patients in the control group used clopidogrel for intervention in the treatment, while the patients in the observation group used aspirin enteric coated tablets in the treatment. Thrombin activation time (APTT), plasma fibrinogen (FIB), prothrombin time (PT), platelet count (PLT) and the overall treatment effectiveness were compared between the two groups before and after treatment.
Results There was no significant difference between the two groups before treatment (P>0.05). After the intervention of drug therapy, there was no significant difference in platelet count between the two patients (P>0.05). The plasma fibrinogen of patients in the observation group was significantly lower than that of the control group. In terms of thrombin activation time and prothrombin time, patients in the observation group were significantly longer than those in the control group, with significant difference (P<0.05). The two groups were compared in terms of overall treatment efficiency. The patients in the observation group were significantly better. The difference was significant (P<0.05).
Conclusion   Aspirin Rongchuang Tablet has a more obvious therapeutic effect in the clinical treatment of transient ischemic attack. After drug intervention, patients' coagulation function indicators can be actively improved, which has great clinical promotion value.