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Open Access Article

International Journal of Medicine and Data. 2022; 6: (5) ; 95-97 ; DOI: 10.12208/j.ijmd.20220212.

Effect of intraperitoneal thermoperfusion chemotherapy on gastrointestinal function and immune functionin patients with advanced gastric cancer
腹腔热灌注化疗对晚期胃癌患者胃肠道功能和免疫功能的影响

作者: 苗妍 *

西京医院 陕西西安

*通讯作者: 苗妍,单位:西京医院 陕西西安;

发布时间: 2022-10-20 总浏览量: 380

摘要

对晚期胃癌的患者予以腹腔热灌注化疗,分析对其免疫功能、胃肠道功能影响探究。方法:选取我院2020年9月1日至2022年9月1日期间诊治的40例患者参与研究,将其分为两组,研究组予以腹腔热灌注,对照组予以等量生理盐水灌注,每组患者20例,比较两组免疫功能、胃肠道反应等。结果:研究组免疫功能指标改善效果优于对照组,研究组胃肠道功能恢复效果优于对照组,临床对比具备统计学差异,(P<0.05)。结论:临床救治胃癌患者晚期症状期间予以腹腔热灌注化疗,具有极高的临床应用价值,能够有效改善患者免疫功能,促进胃肠道功能恢复,减少并发症发生,提高患者生存质量,值得临床推广使用。

关键词: 免疫功能;胃肠道功能;腹腔热灌注化疗

Abstract

to analyze the effect of intraperitoneal hyperthermic perfusion chemotherapy on immune function and gastrointestinal function of patients with advanced symptoms of gastric cancer.
Methods: 40 patients diagnosed and treated in our hospital were selected to participate in the study, and they were divided into groups according to chemotherapy methods. The study group received intraperitoneal hyperthermic perfusion chemotherapy, and the control group received normal saline perfusion. There were 20 patients in each group. The immune function, gastrointestinal Road reaction etc.
Results:The improvement effect of immune function indicators in the study group was better than that in the control group, and the recovery effect of gastrointestinal function in the study group was better than that in the control group, and the clinical comparison was statistically significant (P<0.05).
Conclusion  : Intraperitoneal hyperthermic perfusion chemotherapy during the clinical treatment of advanced symptoms of gastric cancer patients has extremely high clinical application value, can effectively improve the immune function of patients, promote the recovery of gastrointestinal function, reduce the occurrence of complications, and improve the quality of life of patients, which is worthy of clinical promotion.

Key words: immune function; Gastrointestinal function; Intraperitoneal thermoperfusion chemotherapy

参考文献 References

[1] 张涛,李雁,廖成功,刘晓晨,李鑫宝,杨雪,李唯,刘理礼.三种不同置管方式腹腔热灌注化疗的流速和温度比较的动物实验[J].现代肿瘤医学,2022,30(15):2680-2684.

[2] 闵涛,刘丽华,李鑫月,张思奇.顺铂腹腔热灌注联合静脉化疗治疗胃癌疗效及对血清IGF-1 VEGF EGFR水平的影响[J].河北医学,2022,28(03):451-456.

[3] 王学博,符攀峰,任红娟,李松,陈芳,渣盈冰,杨冉.紫杉醇、顺铂方案联合腹腔热灌注化疗对晚期卵巢癌病人免疫功能及生存质量的影响[J].安徽医药,2022,26(04):791-795.

[4] 林曜,沈楚,郭熙恺,李源,王点石,陈鑫,王征,吴轲,陶凯雄,吴川清.腹腔热灌注化疗预防局部进展期胃癌患者根治术切除后腹膜转移的安全性评价[J].中华胃肠外科杂志,2022,25(01):48-55.

[5] 柏巍松,申力,唐纪全,王志伟,王守立,赵立志,申志成.术中腹腔热灌注化疗联合全腹腔镜下胃癌D2根治术治疗胃癌的临床分析[J].肿瘤研究与临床,2021,33(11):834-839.

[6] 孔宪诚,黄建平,阎良,汤雪峰.腹腔热灌注化疗治疗不同Borrmann分型进展期胃癌的临床效果及对肿瘤标志物的影响[J].中国肿瘤外科杂志,2021,13(04):372-376.

[7] 丁平安,杨沛刚,田园,郭洪海,刘洋,郑涛,檀碧波,张志栋,王冬,李勇,赵群.腹腔热灌注化疗在胃癌治疗规范化实施中的经验分享[J].肿瘤综合治疗电子杂志,2021,7(03):51-54.

[8] 李小华,王玉汶,陈育忠,许志恒,陈镇瑶.针刺联合隔姜灸治疗胃癌根治术后腹腔热灌注化疗患者临床疗效观察[J].广州中医药大学学报,2021,38(07):1384-1390.

[9] Leigh N, Solomon D, Pletcher E, Labow DM, Magge DR, Sarpel U, Golas BJ. The importance of primary tumor origin in gastrointestinal malignancies undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. World J Surg Oncol. 2020 Jul 23;18(1):182-189.

[10] 汪舸,王胜斌,居霞,胡胜红,徐四七,余析桐,疏腾.利多卡因复合右美托咪定对胃癌根治联合术中腹腔热灌注化疗患者的影响[J].医学信息,2021,34(10):83-87.

[11] 杨肖军,熊斌.腹腔热灌注化疗在胃肠道恶性肿瘤腹膜转移中的应用[J].临床外科杂志,2019,27(05):443-446.

[12] 周志林,梅勇,戴军,杨旭辉,赵志辉.胃癌根治术后腹腔热灌注化疗对患者血清CEA、CA19-9水平及免疫功能的影响[J].现代生物医学进展,2019,19(03):477-481.

[13] Mielko J, Rawicz-Pruszyński K, Sędłak K, Gęca K, Kwietniewska M, Polkowski WP. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Surface Malignancies: Learning Curve Based on Surgical and Oncological Outcomes. Cancers (Basel). 2020Aug 23;12(9):2387-2394.

[14] 李宗圜,王晓盈,蒋华.腹腔热灌注化疗治疗胃癌的研究现状[J].大连医科大学学报,2022,44(01):75-79.

引用本文

苗妍, 腹腔热灌注化疗对晚期胃癌患者胃肠道功能和免疫功能的影响[J]. 国际医学与数据杂志, 2022; 6: (5) : 95-97.