摘要
目的 观察急性缺血性脑卒中(AIS)后轻中度血管性认知障碍(VCI)采取尤瑞克林联合丁苯酞治疗的效果。方法 选取2020年7月至2021年7月收治的AIS后轻中度VCI患者80例，随机分为观察组和对照组各40例，对照组采取尤瑞克林治疗，观察组给予尤瑞克林+丁苯酞治疗，对比效果。结果 观察组MMSE评分及MOCA评分均高于对照组（P<0.05）；观察组BDNF水平及SOD水平均高于对照组（P<0.05）；观察组MDA水平低于对照组（P<0.05）；两组不良反应发生率组间对比（P>0.05）。结论 尤瑞克林与丁苯酞联合治疗AIS后轻中度VCI患者可以有效改善其认知障碍，保护患者神经元，同时安全性较高。
关键词： 轻中度血管性认知障碍；尤瑞克林；认知功能；丁苯酞；不良反应；血清指标
Abstract
Objective To observe the effect of urekline combined with butylphthalide in the treatment of mild to moderate vascular cognitive impairment (VCI) after acute ischemic stroke (AIS). Methods From July 2020 to July 2021, 80 patients with mild to moderate VCI after AIS were selected and randomly divided into the observation group and the control group, with 40 cases in each group. The control group was treated with urekline, while the observation group was treated with urekline + butylphthalide, and the effects were compared. Results The MMSE score and MOCA score of the observation group were higher than those of the control group (P<0.05). The levels of BDNF and SOD in the observation group were higher than those in the control group (P<0.05). The level of MDA in observation group was lower than that in control group (P<0.05). The incidence of adverse reactions was compared between the two groups (P>0.05). Conclusion The combination of urekline and butylphthalide in the treatment of patients with mild to moderate VCI after AIS can effectively improve their cognitive impairment, protect their neurons, and has high safety.
Key words： Mild to moderate vascular cognitive impairment; Eugene Klin; Cognitive function; Butyl phthalide. Adverse reactions; Serum index
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