Open Access Article
International Journal of Medicine and Data. 2022; 6: (4) ; 18-21 ; DOI: 10.12208/j.ijmd.20220144.
Deer antler regulates cartilage-related gene/protein expression in rats with osteoarthritis based on TGF-β/Smads signaling pathway
鹿茸基于TGF-β/Smads信号通路调控骨关节炎大鼠软骨相关基因/蛋白表达的研究
作者：
卢贺 *,
李政,
任香儒,
欧传双,
李长树,
李雳
深圳平乐骨伤科医院（深圳市坪山区中医院） 广东深圳
*通讯作者：
卢贺,单位：深圳平乐骨伤科医院（深圳市坪山区中医院） 广东深圳；
发布时间: 2022-09-06 总浏览量: 436
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万方数据（WANFANG DATA）
摘要
目的 研究鹿茸基于TGF-β/Smads信号通路对骨关节炎大鼠软骨相关基因/蛋白表达的影响。方法 选择30只健康雌性SD大鼠，体重(220±15)g，随机分为2组，对照组组及研究组，每组15只。结论骨性关节炎发病的重要机制之一与软骨细胞内的 smad2、3、6、7 腈水解酶1（Nit1）、骨诱导因子（Ogn）、脂联素（Adipoq）、过氧化物酶体增殖物激活受体γ（PPRγ）基因及蛋白的异常表达密切相关；中药鹿茸可调控腈水解酶1（Nit1）、骨诱导因子（Ogn）、脂联素（Adipoq）、过氧化物酶体增殖物激活受体γ（PPRγ）的表达影响软骨细胞内 TGF-β/Smads信号通路中关键靶点Smad2、3、6、7 基因及蛋白的表达来修复关节软骨，以此达到治疗骨关节炎的作用。
关键词： 骨关节炎；鹿茸；软骨；信号转导
Abstract
Objective To study the effect of deer antler on the expression of cartilage-related genes/proteins in osteoarthritis rats based on TGF-β/Smads signaling pathway. Methods Thirty healthy female SD rats with a body weight of (220±15) g were selected and randomly divided into 2 groups, the control group and the research group, with 15 rats in each group. Conclusion One of the important mechanisms of osteoarthritis is related to smad2, 3, 6, 7 nitrilase 1 (Nit1), osteoinductive factor (Ogn), adiponectin (Adipoq) and peroxidase in chondrocytes. The abnormal expression of proliferator-activated receptor γ (PPRγ) gene and protein is closely related; Chinese medicine deer antler can regulate nitrilase 1 (Nit1), osteoinductive factor (Ogn), adiponectin (Adipoq), peroxisome The expression of proliferator-activated receptor γ (PPRγ) affects the expression of key target Smad2, 3, 6, 7 genes and proteins in the TGF-β/Smads signaling pathway in chondrocytes to repair articular cartilage, so as to achieve the treatment of osteoarthritis. effect.
Key words： Osteoarthritis; Deer antler; Cartilage; Signal transduction
参考文献 References
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引用本文
卢贺, 李政, 任香儒, 欧传双, 李长树, 李雳, 鹿茸基于TGF-β/Smads信号通路调控骨关节炎大鼠软骨相关基因/蛋白表达的研究[J]. 国际医学与数据杂志, 2022; 6: (4) : 18-21.