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Open Access Article

International Journal of Medicine and Data. 2022; 6: (4) ; 15-17 ; DOI: 10.12208/j.ijmd.20220143.

Genistein, a natural estrogen that affects human health
Genistein,影响人类健康的天然雌激素

作者: 李娜 *, 潘英, 赵禹

深圳市宝安区中心医院 深圳

*通讯作者: 李娜,单位:深圳市宝安区中心医院 深圳;

发布时间: 2022-09-06 总浏览量: 728

摘要

天然雌激素是指能够与体内雌激素受体结合并发挥与雌激素相同作用的植物固醇。Genistein,是一种从大豆中提取的天然植物雌激素,被认为具有化学保护作用,可用为多种激素紊乱的替代疗法,包含乳腺癌、前列腺癌、心血管疾病、骨质疏松症或更年期症状等。另一方面,Genistein也可能被认为是内分泌干扰物,可能对某些人口的健康状况或环境产生负面影响。这篇综述主要讨论Genistein生物特性、疾病相关性及潜在风险,探讨其对人类健康的利与弊。

关键词: Genistein;疾病;健康;潜在风险

Abstract

Natural estrogen refers to phytosterols that can bind to estrogen receptors in vivo and play the same role as estrogen. Genistein, a natural phytoestrogen extracted from soybean, is considered to have chemical protection and can be used as a replacement therapy for various hormone disorders, including breast cancer, prostate cancer, cardiovascular disease, osteoporosis or menopause symptoms. On the other hand, Genistein may also be considered as an endocrine disruptor, which may have a negative impact on the health status of some populations or the environment. This review mainly discusses the biological characteristics, disease correlation and potential risks of Genistein, and discusses its advantages and disadvantages to human health.

Key words: Genistein; disease; Health; The potential risk

参考文献 References

[1] Tuli H S, Tuorkey M J, Thakral F, et al. Molecular Mechanisms of Action of Genistein in Cancer: Recent Advances. Front Pharmacol, 2019. 10: p. 1336.

[2] Oparil S, Acelajado M C, Bakris G L, et al. Hypertension. Nat Rev Dis Primers, 2018. 4: p. 18014.

[3] Tit D M, Bungau S, Iovan C, et al. Effects of the Hormone Replacement Therapy and of Soy Isoflavones on Bone Resorption in Postmenopause. J Clin Med, 2018. 7(10).

[4] Wu G J, Chen J T, Cherng Y G, et al. Genistein Improves Bone Healing via Triggering Estrogen Receptor Alpha-Mediated Expressions of Osteogenesis-Associated Genes and Consequent Maturation of Osteoblasts. J Agric Food Chem, 2020. 68(39): p. 10639-10650.

[5] Hwang Y H, Kim T, Kim R, et al. Magnolol Inhibits Osteoclast Differentiation via Suppression of RANKL Expression. Molecules, 2018. 23(7).

[6] 朱艳琼,韩宝三. 天然雌激素雌酮、雌二醇和雌三醇的分析检测进展[J]. 化学世界,2020,61(04):237-244.

[7] 刘小帆. 基于鲫鱼原代肝细胞酶联免疫法检测9种雌激素及未知雌激素的筛查[D].山东师范大学,2020.

[8] 朱艳琼,韩宝三. 天然雌激素的分析检测进展[J/OL]. 化学世界,2020(04)[2022-08-05].https://doi.org/10.19500/j.cnki.0367-6358.20190715.

[9] 梁莹莹. Genistein对冻融猪精子质量的影响及机理研究[D].广西大学,2020.

[10] 李雯,李毅,王中卫,任洪涛,张杨,杨鹏涛,潘淑沛,王亚利. Genistein通过上调Cyclin D1和CDK4的表达促进卵巢癌OVCAR-5细胞的增殖[J]. 西安交通大学学报(医学版),2021,42(01):59-64.


引用本文

李娜, 潘英, 赵禹, Genistein,影响人类健康的天然雌激素[J]. 国际医学与数据杂志, 2022; 6: (4) : 15-17.